Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition-a great story published in Science from Dr. Carl Nathan lab at Weill Cornell Medicine!!

http://science.sciencemag.org/content/363/6426/eaau8959.long A wrench in the gears of life Tuberculosis is a global health crisis that threatens to become worse as resistance to existing drugs emerges. Identifying ideal targets for drug development requires knowledge of weak points in biochemical pathways that are specific for the pathogen but are absent in hosts. Ballinger et al. identified a […]

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High-fructose corn syrup enhances intestinal tumor growth in mice-the first biochemical link between colon cancer with soda, important and impressive research from Drs. Jihye Yun, Kyu Rhee and Lewis Cantley lab!!

http://science.sciencemag.org/content/363/6433/1345/tab-article-info Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. […]

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Plasma metabolomic profiles enhance precision medicine for volunteers of normal health: a wonderful work published in PNAS from Dr. Thomas Caskey lab and Metabolon Inc.

https://www.ncbi.nlm.nih.gov/pubmed/?term=26283345 Precision medicine, taking account of human individuality in genes, environment, and lifestyle for early disease diagnosis and individualized therapy, has shown great promise to transform medical care. Nontargeted metabolomics, with the ability to detect broad classes of biochemicals, can provide a comprehensive functional phenotype integrating clinical phenotypes with genetic and nongenetic factors. To test […]

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Mass Spectrometric Identification of Urinary Biomarkers of Pulmonary Tuberculosis: a great study on clinical biomarker discovery published in EBioMedicine from Dr. Kyu Rhee lab at Weill Cornell Medicine!!

https://www.ebiomedicine.com/article/S2352-3964(18)30142-7/abstract BackgroundTuberculosis (TB) is the leading infectious cause of death worldwide. A major barrier to control of the pandemic is a lack of clinical biomarkers with the ability to distinguish active TB from healthy and sick controls and potential for development into point-of-care diagnostics. MethodsWe conducted a prospective case control study to identify candidate urine-based […]

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The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet-a charming topic published in Cell from Dr. Elaine Y. Hsiao lab at UCLA

https://www.cell.com/cell/fulltext/S0092-8674(18)30520-8 The ketogenic diet (KD) is used to treat refractory epilepsy, but the mechanisms underlying its neuroprotective effects remain unclear. Here, we show that the gut microbiota is altered by the KD and required for protection against acute electrically induced seizures and spontaneous tonic-clonic seizures in two mouse models. Mice treated with antibiotics or reared […]

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